Antibodies are an essential tool for basic research, development of diagnostic tests and therapeutics for human disease. Extracellular vesicles (EVs), including exosomes, express antigens with 3D conformations and/or post-translational modifications that often differ from the cellular counterpart. For this reason, most of the antibodies currently available on the market fail to recognize exosome-associated antigens with sufficient sensitivity and specificity. In collaboration with Exosomics Siena Spa, HBM has validated a list of polyclonal and monoclonal antibodies against common (CD63, CD81, ALIX) and disease- specific (cancer and neurodegenerative diseases) exosomal markers.
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