Support Online
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    Senior scientist - Paolo Guazzi
    Call: +372 656 1996
    paolo.guazzi@hansabiomed.eu
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    Product specialist - Julia Gavrilova
    Call: +372 656 1996
    julia@hansabiomed.eu

Antibodies

Antibodies are an essential tool for basic research, development of diagnostic tests and therapeutics for human disease. Extracellular vesicles (EVs), including exosomes, express antigens with 3D conformations and/or post-translational modifications that often differ from the cellular counterpart. For this reason, most of the antibodies currently available on the market fail to recognize exosome-associated antigens with sufficient sensitivity and specificity. In collaboration with Exosomics Siena Spa, HBM has validated a list of polyclonal and monoclonal antibodies against common (CD63, CD81, ALIX) and disease- specific (cancer and neurodegenerative diseases) exosomal markers.

References:

Gagni, P., Cretich, M., Benussi, L., Tonoli, E., Ciani, M., Ghidoni, R., ... & Chiari, M. (2015). Combined mass quantitation and phenotyping of intact extracellular vesicles by a microarray platform. Analytica Chimica Acta.

Rampini, S., Kilinc, D., Li, P., Monteil, C., Gandhi, D., & Lee, G. U. (2015). Micromagnet arrays for on-chip focusing, switching, and separation of superparamagnetic beads and single cells. Lab on a Chip, 15(16), 3370-3379.

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